Best Supplements for Stress and Anxiety (2026 Guide)

Written by Ryan Pepple, Founder, Shuven. Originally published April 8, 2026. Last updated September 4, 2026.

On this page: How chronic cortisol damages you · Signs your stress response is off · Why most formulas don't work · The nine supplements · When to get professional help · FAQ · References

The best supplements for stress and anxiety work on three fronts at once: an adaptogen to lower cortisol (KSM-66® ashwagandha at 300–600 mg), calming amino acids and minerals that support GABA activity (L-theanine and magnesium glycinate), and gut-repair ingredients that support the gut-brain axis. Shuven™ Reset delivers KSM-66 at 600 mg alongside L-glutamine, slippery elm, and marshmallow root to address the stress-gut loop from both ends.

If you wake up tired, feel anxious for no clear reason, can't focus, and crash by mid-afternoon, your body isn't broken. It's often stuck in a chronic stress loop driven by elevated cortisol, a depleted nervous system, and a gut whose signaling to the brain has been disrupted.

The standard advice — "manage your stress" — misses part of the point. You can't meditate your way out of a hormonal imbalance. But the opposite error matters just as much: an anxiety disorder is a medical condition, and no supplement substitutes for treatment. This guide covers the physiological levers, and it will tell you plainly where those levers stop being enough.

What follows is the 9 supplements for anxiety and stress with the strongest research behind them, what the studied doses actually look like, which forms to buy, which to skip, and the safety issues most pages in this category leave out.

How Chronic Cortisol Damages Your Body

Cortisol is your body's primary stress hormone, produced by the adrenal glands. In short bursts, it's essential — it wakes you up in the morning, fuels you during a workout, and helps you respond to a real threat.

But when cortisol stays elevated for weeks, months, or years — which it does for many modern adults — it becomes destructive:

• Disrupts sleep architecture — fragments deep recovery cycles and prevents the restorative slow-wave sleep your nervous system needs to reset
• Dampens serotonin and dopamine signaling in the brain — flattens mood, motivation, and reward response over time
• Damages the gut lining and triggers inflammation — a human study published in Gut^[1] found that acute psychological stress directly increased intestinal permeability through a cortisol-dependent mechanism — the same zonulin-mediated pathway at the center of leaky gut repair
• Increases belly fat and blood sugar dysregulation — promotes visceral fat storage and insulin resistance through HPA-axis dysfunction
• Weakens the immune system — suppresses secretory IgA at the gut barrier and slows tissue healing
• Drives anxiety, irritability, and brain fog — overactivates the amygdala and impairs prefrontal cortex function, the cognitive signature of chronic stress
• Depletes magnesium, B vitamins, and other key cofactors — burns through the nutrients your body needs to make neurotransmitters and regulate the HPA axis

Research on adaptogenic herbs has shown that the right supplementation can reduce cortisol, perceived stress, and anxiety scores in adults. In a randomized, double-blind, placebo-controlled trial published in the Indian Journal of Psychological Medicine^[2], 60 days of KSM-66 ashwagandha at 600 mg per day produced a statistically significant reduction in serum cortisol (P=0.0006) compared to placebo, alongside significant improvements across every stress-assessment scale used (P<0.0001). That's a measurable intervention rather than a band-aid — though as the safety section below covers, ashwagandha is also the one ingredient here with a real risk worth understanding first.

7 Signs Your Stress Response Is Dysregulated

If three or more of these sound familiar, your cortisol rhythm may be out of sync:

1. You wake up between 2–4 a.m. and can't fall back asleep. A classic sign of cortisol surging when it should be at its lowest — our breakdown of why you wake up at 3 a.m. explains the mechanism, and it responds well to a targeted nighttime cortisol and nervous system protocol.
2. You feel "wired but tired." Mentally exhausted but physically unable to relax.
3. You crash hard in the afternoon. Cortisol crashes mid-day, often paired with sugar cravings or caffeine dependence.
4. You feel anxious for no specific reason. Free-floating anxiety often has a physical component alongside a psychological one — our guide to anxiety that appears without a trigger covers what's driving it.
5. You're gaining weight around your midsection. Cortisol drives visceral fat storage even when diet hasn't changed.
6. You catch every cold. High cortisol suppresses immune function over time.
7. You feel emotionally flat or unmotivated. Chronic stress depletes dopamine and serotonin precursors, leaving you numb instead of energized.

If this list describes your last 6 months, it's worth addressing the stress-gut root cause rather than chasing symptoms one at a time. It's also worth knowing that several items on that list — persistent worry, flat mood, sleep disruption — overlap with anxiety and depressive disorders, which need assessment rather than a supplement. The section on professional help below covers where that line sits.

Why Most Anxiety Supplements Don't Work

Walk into any health store and you'll find dozens of "calm," "stress," and "anxiety" formulas. Most don't work. Here's why:

1. Underdosed ingredients. The clinical research on ashwagandha uses 300–600 mg of standardized extract daily. Most supplements contain 100–200 mg of generic, non-standardized ashwagandha — a fraction of the studied amount.

2. Proprietary blends hide individual doses. When a label says "Calm Blend: 800 mg" without breaking down each ingredient, it's almost always because the doses are too small to disclose individually.

3. They ignore the gut-brain axis. Your gut and brain are in constant two-way communication through the vagus nerve, immune signaling, and the short-chain fatty acids your gut bacteria produce. Cleveland Clinic describes that connection as complex and bidirectional^[3], with health or disease in one system affecting the other. When chronic stress damages the gut lining and disrupts the microbiome, that signaling degrades — and most stress formulas don't touch it. For a deeper look, see our complete guide to gut-brain axis supplements.

4. They sedate instead of support. Heavy CBD, melatonin, and GABA pills mask symptoms without addressing why cortisol is elevated in the first place. Oral GABA also crosses the blood-brain barrier poorly, which limits how much of a GABA capsule reaches the brain at all.

5. They use synthetic fillers. Magnesium stearate, titanium dioxide, and artificial colors are common in low-quality formulas and can themselves contribute to gut inflammation.

None of this is illegal, which is worth understanding rather than resenting. As the NIH Office of Dietary Supplements explains^[4], medicines require FDA approval before they can be sold while supplements do not — companies must hold evidence that their products are safe and their labeling truthful, but generally aren't required to submit it in advance. A clean, fully disclosed formula will outperform a kitchen-sink blend every time.

9 Best Supplements for Stress and Anxiety: Quick Comparison

9 Best Supplements for Stress and Anxiety: Deep Dive

1. KSM-66 Ashwagandha

The most-studied adaptogen in the world, and for good reason. Ashwagandha modulates the HPA axis — your body's stress command system — bringing cortisol down when it's chronically elevated.

Ashwagandha withanolides directly influence the hypothalamic-pituitary-adrenal pathway, helping your body return to baseline after stress rather than staying locked in fight-or-flight. Chronic cortisol elevation doesn't just affect mood — human studies show psychological stress directly increases intestinal permeability via the same zonulin-mediated tight-junction mechanism covered in our gut barrier guide, which is why gut lining repair supplements are often the missing piece for people whose stress symptoms come with digestive flare-ups.

A landmark randomized, double-blind, placebo-controlled trial^[2] found that 300 mg of high-concentration ashwagandha root extract twice daily for 60 days produced a significant reduction in stress assessment scores and a substantial drop in serum cortisol versus placebo. Look specifically for KSM-66, the patented root-only extract used in most major clinical studies, dosed at 300–600 mg daily.

A safety issue this category rarely prints. Ashwagandha has been implicated in cases of clinically apparent liver injury, and the NIH's LiverTox database^[5] classifies it as a probable cause. In the reported cases, injury typically appeared 2 to 12 weeks after starting, usually with a cholestatic or mixed pattern involving jaundice and itching. These cases are rare against very widespread use, and clinical trials have not shown liver enzyme elevations — but they are documented, and several involved products where the labeled contents were uncertain. Practical implications: don't take ashwagandha if you have existing liver disease, stop and see a doctor promptly if you develop jaundice, dark urine, persistent itching, or unexplained nausea and fatigue, and buy only third-party-tested products from brands that disclose the extract and its standardization. We'd rather you know this and choose deliberately than find it somewhere else after the fact.

2. L-Theanine

An amino acid found in green tea leaves that increases alpha brain wave activity — the same brainwave pattern seen during meditation. The result is calm focus without sedation.

L-theanine influences GABA, serotonin, and dopamine activity in the brain while reducing excitatory glutamate. This combination produces measurable calm without making you drowsy.

A randomized, double-blind, placebo-controlled crossover trial published in Nutrients^[6] gave healthy adults Suntheanine at 200 mg daily for four weeks and recorded significant reductions in trait anxiety scores, depressive symptom scores, and sleep-quality complaints compared with placebo. Look for Suntheanine, the patented pure L-isomer form, dosed at 200–400 mg daily.

3. Magnesium Glycinate

Magnesium is involved in over 300 enzymatic reactions, many of which regulate the nervous system. Low magnesium is linked to higher cortisol, poor GABA signaling, and increased anxiety.

Magnesium acts at GABA receptors — the brain's primary calming system — lowers cortisol output, and reduces the muscle tension and palpitations that often travel with anxiety.

A randomized clinical trial in healthy adults with low magnesium status^[7] found that 300 mg of daily magnesium significantly reduced stress scores on the validated DASS-42 stress subscale over 8 weeks, with an additional benefit when paired with vitamin B6 in the most severely stressed participants.

Choose magnesium glycinate (gentle on the stomach) or magnesium threonate (crosses the blood-brain barrier), and avoid magnesium oxide, which is poorly absorbed and can cause diarrhea. Dose at 200–400 mg of elemental magnesium daily — and note that the NIH Office of Dietary Supplements^[8] sets the upper limit for supplemental magnesium at 350 mg per day, which applies only to supplements and medications rather than magnesium from food. Supplement Facts panels state elemental magnesium, so that's the number to compare against research.

4. Saffron Extract (affron)

One of the most underrated mood and stress supplements available. Multiple clinical trials have measured saffron extract's effect on low mood and anxiety scores.

Saffron's active compounds — crocin and safranal — influence serotonin and dopamine availability in the brain while reducing inflammatory cytokines associated with low mood.

A randomized, double-blind, placebo-controlled trial published in The Journal of Nutrition^[9] supplemented 202 adults experiencing low mood with 28 mg of standardized saffron extract daily for 12 weeks and measured significantly greater reductions in depression, anxiety, and stress scale scores than placebo, with improvements appearing as early as week five. Look for affron, the standardized branded form, at 28–30 mg daily — the dose used in clinical trials. If low mood rather than stress is your main concern, that is a reason to speak with a doctor as well as to consider a supplement.

5. Rhodiola Rosea

A high-altitude adaptogen traditionally used in Scandinavian and Russian medicine to combat fatigue and stress. Rhodiola works best for the "burned out and exhausted" presentation of stress rather than acute panic.

Rhodiola helps regulate cortisol response and supports adrenal recovery in people dealing with chronic stress and mental fatigue.

A randomized, double-blind, placebo-controlled trial published in Planta Medica^[10] gave 60 adults with stress-related fatigue 576 mg of standardized SHR-5 Rhodiola extract daily for 28 days and found significant improvements in fatigue levels, attention on computerized performance testing, and a reduced salivary cortisol response to awakening. The wider evidence base is mixed, so treat it as promising rather than settled. Look for standardization to 3% rosavins and 1% salidroside, dosed at 200–576 mg daily, taken in the morning — it can be too activating in the evening.

6. Lemon Balm Extract

A traditional calming herb from the mint family that supports GABA activity and has been studied for acute stress and anxiety symptoms. Useful for both daily stress and situational tension.

Lemon balm inhibits the enzyme that breaks down GABA, supporting your brain's primary calming neurotransmitter.

A systematic review and meta-analysis published in Phytotherapy Research^[11] pooled ten randomized trials and found significant improvements in both anxiety and depression scores compared with placebo, across preparations dosed from 300 mg to 5,000 mg daily. Look for standardized lemon balm extract, dosed at 300–600 mg daily.

7. B-Complex (Specifically B6, B12, and Folate)

B vitamins are cofactors for producing the neurotransmitters your nervous system needs to function — including serotonin, dopamine, and GABA. Chronic stress depletes them faster than most diets can replace.

Vitamin B6 is required to convert tryptophan into serotonin. B12 and folate support methylation, the process that controls how your brain processes mood-regulating chemicals.

A 2022 randomized controlled trial published in Human Psychopharmacology^[12] found that one month of high-dose vitamin B6 supplementation significantly reduced self-reported anxiety in young adults, with sensory testing consistent with increased GABA activity. Vitamin B12 showed no comparable effect.

An important safety note on B6. That trial used 100 mg per day, which sits right at the US tolerable upper intake level and far above the far more conservative limit European regulators adopted. The NIH Office of Dietary Supplements^[13] sets the US upper limit at 100 mg daily for adults, while the European Food Safety Authority lowered its limit to 12 mg per day in 2023, because sustained high B6 intake is associated with sensory nerve problems. A one-month research protocol under supervision is not the same as taking 100 mg indefinitely. For daily use, keep your total from all sources modest — under the European 12 mg figure is a defensible target — unless a clinician is supervising something higher.

Look for methylated forms only: methylfolate (not folic acid), methylcobalamin (not cyanocobalamin), and pyridoxal-5-phosphate (P5P) for B6. Many people have genetic variants that prevent them from properly using synthetic B vitamins.

8. Omega-3 Fatty Acids (EPA-Dominant)

Your brain is roughly 60% fat, and the structure of every neuron in your brain depends on omega-3s. EPA specifically reduces neuroinflammation, which is increasingly recognized as a driver of low mood and anxiety.

EPA reduces inflammatory cytokines that interfere with serotonin signaling in the brain and disrupt the gut-brain axis. The anti-inflammatory effect compounds over weeks.

A systematic review and meta-analysis in JAMA Network Open^[14] pooled 19 clinical trials covering 2,240 participants across 11 countries and concluded that omega-3 treatment was associated with reduced anxiety symptoms compared with controls, with stronger effects in people who had a clinical condition than in subclinical populations. A later dose-response meta-analysis in BMC Psychiatry^[15] refined the picture: benefit scaled with dose, and the greatest improvement occurred around 2 g per day, with lower doses showing little effect.

That dose-response finding matters when you're reading labels. Aim for at least 1,000 mg of EPA daily, and understand that the strongest evidence sits closer to 2 g of total omega-3s. Algal oil is a vegan option that delivers the same neuroinflammation reduction as fish oil; if you're not vegan, triglyceride-form fish oil is equally effective. Third-party testing for heavy metals is non-negotiable either way. High-dose fish oil can also thin the blood, so check with your doctor if you take anticoagulants.

9. L-Glutamine

The amino acid the gut uses to fuel its own repair. Stress damages the gut lining within hours, and a damaged lining degrades the gut-brain signaling that helps keep the nervous system settled. L-glutamine is the bridge that connects gut repair to stress support.

L-glutamine is the primary fuel source for enterocytes — the cells of the intestinal lining — helping them rebuild tight junctions and restore barrier function. A healthy gut barrier means better gut-brain signaling and lower systemic inflammation.

A randomized, double-blind, placebo-controlled trial published in Gut^[16] found that eight weeks of oral L-glutamine significantly reduced intestinal permeability and symptom severity compared with placebo. Two things are worth knowing about that trial before you read a label: it enrolled adults with post-infectious IBS and confirmed increased permeability rather than healthy adults, and it used 5 g three times daily — 15 g in total.

That matters for expectations. Capsule products cannot reach 15 g; that dose is 25 or more capsules a day, which is why glutamine in any capsule formula is a supporting amount that contributes fuel to the lining rather than a replication of the trial. If you want trial-level glutamine, a powder is the honest format — pharmaceutical-grade, started low and increased gradually.

What to Avoid in Stress and Anxiety Supplements

Most products on the market have at least one of these red flags. Learn to spot them on a label:

• Proprietary blends that hide individual ingredient doses. If you can't see the milligrams, the doses are almost always too low.
• Generic ashwagandha with no standardization. Without KSM-66 or Sensoril, you have no idea what's actually in the capsule — and the documented liver-injury cases disproportionately involved products whose labeled contents couldn't be verified.
• Heavy melatonin or CBD formulas. These mask symptoms without addressing the root cause and can disrupt your natural cortisol rhythm with long-term use.
• GABA pills. Oral GABA crosses the blood-brain barrier poorly, so much of what you swallow never reaches where it's meant to act.
• Magnesium oxide. Poorly absorbed (around 4% bioavailability) and frequently causes digestive upset, compared to better-absorbed forms like the magnesium glycinate in Shuven Sleep.
• Megadose B6. Anything at or near 100 mg for ongoing daily use, given the nerve-related risks at sustained high intake.
• Synthetic fillers. Magnesium stearate, titanium dioxide, and artificial colors add nothing therapeutic and can worsen gut inflammation.
• No third-party testing. Supplements aren't reviewed like pharmaceuticals before sale. If a brand can't show third-party purity testing, the contents may not match the label.

When Stress and Anxiety Need Professional Care

Everything above addresses physiology. Physiology is not the whole picture, and this is the part of the page that matters most if it applies to you.

Anxiety disorders are common, real, and treatable, and they are not the same thing as an elevated cortisol curve. The National Institute of Mental Health notes^[17] that about a third of US adolescents and adults experience an anxiety disorder at some point in their lives, and that symptoms can interfere with work, schoolwork, and relationships. NIMH's threshold for seeking help is straightforward and worth borrowing: if anxiety is causing problems in everyday life — at work, at school, or with the people around you — it's time to seek professional help.

Effective treatments exist, including psychotherapy, medication, or both, and a primary care provider can refer you to a psychologist, psychiatrist, or clinical social worker. Seeking that out isn't a failure of self-management, and it doesn't mean you stop supporting the physiology underneath — the two work alongside each other.

Some symptoms warrant medical attention rather than a supplement protocol: panic attacks, persistent low mood or loss of interest lasting more than two weeks, anxiety that stops you leaving the house or doing your job, or symptoms that keep worsening despite consistent changes. If you're having thoughts of harming yourself, please treat that as urgent rather than something to manage alone. In the United States you can call or text 988 to reach the Suicide and Crisis Lifeline, free and available 24 hours a day.

How Shuven Reset Supports Stress and Anxiety

Shuven Reset was formulated as the inverse of the red-flag list above. Every amount is printed on the label, the ashwagandha is standardized KSM-66 at the full 600 mg studied dose, and nothing is hidden behind a proprietary blend. Where an ingredient sits below its trial dose — as glutamine does in any capsule — the label shows you, rather than implying otherwise.

No fillers. No proprietary blends. Vegan, gluten-free, non-GMO. Third-party tested. You can start your 30-day stress and gut reset with Shuven Reset and see how each ingredient targets a different driver of chronic stress. If digestive symptoms travel with your stress, our guide to repairing the gut barrier under chronic stress covers that side in more depth.

For evening recovery, the Albion TRAACS Magnesium Glycinate 300 mg, Suntheanine L-Theanine 200 mg, Glycine 1,000 mg, Lemon Balm Extract 150 mg, Passionflower Extract 150 mg, and Apigenin 50 mg combination in Shuven Sleep covers the calming nervous-system ingredients Reset doesn't include.

Daily Habits That Lower Cortisol Faster

Supplements work better when paired with these basics:

• Get outside within 30 minutes of waking. Natural light entrains your cortisol awakening response and resets the entire circadian rhythm.
• Eat 25–30 g of protein at breakfast. Stabilizes blood sugar and prevents the mid-morning cortisol surge from a glucose crash.
• Limit caffeine after noon. Caffeine has a 5–6 hour half-life and prolongs cortisol elevation late into the day.
• Lift weights 2–3x per week. Strength training lowers baseline cortisol over time while building stress resilience.
• Practice 5 minutes of slow nasal breathing daily. Directly activates the vagus nerve and shifts you out of sympathetic dominance.
• Sleep before 11 p.m. Late nights spike next-day cortisol and disrupt the entire morning recovery cycle. The sleep and gut health connection runs in both directions here.

You don't need to do all six perfectly. Pick two and build from there.

Frequently Asked Questions

How do I choose the right stress supplement for my needs?

Match the formula to the pattern you actually have. If your stress shows up as digestive flare-ups, food sensitivity, or bloating, start with gut support plus an adaptogen — the gut is part of what's driving the feeling, not just a bystander. If it shows up as 2 a.m. waking and muscle tension, prioritize magnesium glycinate and L-theanine in the evening. If it shows up as burnout and mental fatigue rather than acute anxiety, rhodiola in the morning is the better fit. And if low mood is the dominant feature, saffron has the strongest mood-specific data — alongside a conversation with a doctor. Whatever you pick, check that the dose on the label matches the dose in the research; that single filter eliminates most products on the shelf.

Is ashwagandha safe to take long term?

For most people it's well tolerated, and clinical trials haven't shown liver enzyme elevations. But cases of clinically apparent liver injury have been reported, and the NIH's LiverTox database lists ashwagandha as a probable cause. Injury typically appeared 2 to 12 weeks after starting, with jaundice and itching as common presenting signs. Avoid it entirely if you have liver disease, don't combine it with other hepatotoxic supplements or heavy alcohol use, buy only third-party-tested standardized extracts, and stop and see a doctor if you develop jaundice, dark urine, persistent itching, or unexplained nausea. Ashwagandha is also contraindicated in pregnancy and can interact with thyroid medication, sedatives, and immunosuppressants.

How long until I notice a difference?

Many people feel calmer within 7–14 days of consistent use. Deeper changes — better sleep, lower baseline anxiety, more emotional resilience — typically show up by week 3–4 as cortisol patterns normalize. Individual response varies, and anxiety that doesn't shift across that window is a reason to get assessed rather than to add more products.

Can I take all these supplements together?

The 9 ingredients in this guide are commonly stacked together in clinical protocols and generally work synergistically rather than antagonistically. The cleaner approach is a well-formulated foundation product plus 1–2 targeted additions — magnesium for sleep or omega-3 for inflammation — rather than 9 separate bottles. Watch your combined totals for anything with an upper limit, particularly magnesium and B6, since stacking multiple products is the usual way people exceed them without noticing.

Can supplements help with stress, anxiety, and low mood together?

Several of these ingredients have data across all three. Saffron has the strongest mood-specific evidence, with trials measuring reductions in depression, anxiety, and stress scores from the same 28 mg dose. Omega-3s and lemon balm also show effects spanning anxiety and depressive symptoms. That said, depression and anxiety disorders are clinical conditions that warrant professional assessment. Supplements can support the physiology underneath them — cortisol regulation, neuroinflammation, gut-brain signaling — but they are not a substitute for diagnosis and treatment, and anyone with persistent low mood should speak with a doctor or mental health professional.

Can stress supplements help with brain fog?

Chronic stress is one of the top drivers of foggy thinking. As cortisol drops and gut-brain signaling recovers, focus and clarity often return. For more on this, see our complete guide to the best supplements for brain fog and mental clarity.

Are these supplements safe with anxiety medications?

Always check with your doctor first, and don't stop a prescribed medication to try a supplement. Ashwagandha can interact with thyroid medication, immunosuppressants, and sedatives. High-dose omega-3s can affect clotting. None of the ingredients are inherently dangerous, but interactions matter, especially if you're on SSRIs, benzodiazepines, or thyroid medication.

Are these safe during pregnancy or breastfeeding?

No. Ashwagandha is contraindicated in pregnancy, and several of the herbs in this guide haven't been studied for safety in pregnant or breastfeeding women. Talk to your provider before starting any supplement during this time.

What about magnesium and B vitamins — do I need both?

If you're focused on stress and anxiety specifically, magnesium glycinate is the higher-leverage addition — it's the form built into the Shuven Sleep evening recovery formula at 300 mg, within the studied range. A methylated B-complex is a reasonable companion if you have low energy, brain fog, or known B-vitamin deficiencies, but it isn't required to see results from the core stack, and B vitamins do little for someone whose levels are already adequate.

Why don't most stress supplements include gut-repair ingredients?

Most stress formulas were designed around anxiety as a brain-only problem. The research connecting gut barrier function to gut-brain signaling and anxiety severity is newer — most of the strong evidence is from the last 10 years — and the supplement industry has been slow to update. Including ingredients like L-glutamine, slippery elm, and marshmallow root in a stress formula is still uncommon, but it addresses a driver most products ignore.

The Bottom Line

Chronic stress, high cortisol, and anxiety aren't character flaws — they're physiological states with measurable causes and real, researched levers. The right combination of clinically studied adaptogens, calming amino acids, depleted-cofactor replacement, and gut-support ingredients can shift the loop in weeks rather than years. And where the problem is an anxiety disorder rather than a stress response, the right move is treatment, not a stronger formula — the two aren't in competition.

Shuven Reset is built around the science covered in this guide: KSM-66 Ashwagandha, L-Glutamine, slippery elm, marshmallow root, and ginger — every amount disclosed, in their most bioavailable forms. You can begin the 30-day protocol with Shuven Reset and see how each ingredient targets a different driver of chronic stress, then layer in Shuven Sleep for evening cortisol recovery as your nervous system rebuilds.

References

1. Psychological stress and small intestinal permeability in healthy adults [human study]. Gut. PMID: 24153250
2. KSM-66 Ashwagandha and serum cortisol, randomized double-blind placebo-controlled 60-day trial. Indian Journal of Psychological Medicine. PMID: 23439798
3. Cleveland Clinic. The Gut-Brain Connection. my.clevelandclinic.org/health/body/the-gut-brain-connection
4. NIH Office of Dietary Supplements. Dietary Supplements: What You Need to Know. ods.od.nih.gov/factsheets/WYNTK-Consumer
5. NIH LiverTox Database. Ashwagandha. ncbi.nlm.nih.gov/books/NBK548536
6. Suntheanine L-theanine 200 mg, randomized double-blind placebo-controlled crossover trial. Nutrients. PMCID: PMC6836118
7. Magnesium supplementation and severe stress, randomized clinical trial. PMCID: PMC6298677
8. NIH Office of Dietary Supplements. Magnesium — Health Professional Fact Sheet. ods.od.nih.gov/factsheets/Magnesium-Consumer
9. Saffron extract (affron) and mood/wellbeing, randomized controlled trial. The Journal of Nutrition. jn.nutrition.org/article/S0022-3166(25)00306-2
10. Rhodiola rosea SHR-5 extract and stress-related fatigue, randomized double-blind placebo-controlled trial. Planta Medica. PMID: 19016404
11. Lemon balm, anxiety, and depression: systematic review and meta-analysis. Phytotherapy Research. PMID: 34449930
12. High-dose vitamin B6, anxiety, and GABA activity, randomized controlled trial (2022). Human Psychopharmacology. PMCID: PMC9787829
13. NIH Office of Dietary Supplements. Vitamin B6 — Health Professional Fact Sheet. ods.od.nih.gov/factsheets/VitaminB6-Consumer
14. Omega-3 and anxiety symptom severity, systematic review and meta-analysis. JAMA Network Open. PMCID: PMC6324500
15. Omega-3 dose-response meta-analysis for anxiety symptoms. BMC Psychiatry. PMCID: PMC11186166
16. Randomised placebo-controlled trial of dietary glutamine supplements for post-infectious IBS-D. Gut. PMID: 30108163
17. National Institute of Mental Health. Anxiety Disorders. nimh.nih.gov/health/topics/anxiety-disorders

About the Author

Ryan Pepple is the founder of Shuven, where he researches and formulates supplements built around full-dose transparency — every amount on the label checked against the clinical literature it's based on.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This article is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare practitioner before starting any new supplement, especially if you have a medical condition or take medication.