Best Gut-Brain Axis Supplements: Ingredients That Actually Work
Written by Ryan Pepple, Founder, Shuven. Originally published April 7, 2026. Last updated September 4, 2026.
On this page: What is the gut-brain axis? · How your gut talks to your brain · Seven signs it's out of balance · The best ingredients · How Shuven™ supports it · FAQ · References
The best gut brain axis supplements work on three pathways at once: adaptogens like KSM-66 ashwagandha to support vagal tone, gut-lining nutrients like L-glutamine to reduce inflammatory leakage, and neurotransmitter precursors like L-theanine and L-tyrosine. Shuven Reset and Shuven Focus target the gut and brain ends of the axis together, with every amount printed on the label.
If you've been dealing with anxiety, brain fog, low mood, or sleep that won't reset — and nothing seems to address the root cause — the answer may not be in your brain at all. The gut-brain axis is the bidirectional communication system between your digestive tract and your central nervous system, and emerging research shows it's one of the most underappreciated drivers of mental health symptoms in modern adults.
Most stress and anxiety guides treat the brain in isolation. This one doesn't. This guide breaks down what the gut-brain connection actually is, the seven signs it's out of balance, the supplements with the strongest research behind them, and how our own doses compare to the studies. If you've tried meditation, therapy, and standard supplements without results, the missing piece may be below your diaphragm.
The right combination of gut-supporting, vagus-nerve-activating, and neurotransmitter-precursor nutrients can shift how you feel within weeks. This guide gives you the evidence-backed protocol.
What Is the Gut-Brain Axis?
The gut-brain axis is the two-way communication system linking your digestive tract to your central nervous system, running primarily through the vagus nerve. Unlike some wellness concepts, this one is not contested: Cleveland Clinic describes the connection as complex and bidirectional[1], naming the enteric nervous system, the vagus nerve, and the gut microbiome as its key players, and noting that health or disease in one system affects the other.
Most of your body's serotonin is made in the gut — but not for your brain. Gut serotonin is produced by enterochromaffin cells in the intestinal wall and stays in the digestive tract; it doesn't cross the blood-brain barrier. What it does instead is arguably more interesting: it talks to the brain through a nerve.
The vagus nerve is the longest cranial nerve in your body, connecting your brainstem directly to your gastrointestinal tract. Signals travel in both directions: gut to brain, and brain to gut. Harvard Health frames the practical consequence bluntly[2]: digestive distress can be either the cause or the product of anxiety, stress, or depression, which is why treating a distressed gut without accounting for emotional state so often fails. That's why nervousness causes butterflies, and why a bloated gut can leave you mentally foggy by lunchtime.
A 2025 review published in the International Journal of Molecular Sciences[3] maps the pathway precisely: gut-derived serotonin activates vagal afferent fibers, which transmit signals to the nucleus tractus solitarius (NTS) in the brainstem, and from there modulate serotonergic neurons in the dorsal raphe nucleus and norepinephrinergic neurons in the locus coeruleus. That chain influences emotional regulation, stress response, and immune function. The review also highlights short-chain fatty acids from gut bacteria as enhancers of both serotonin synthesis and vagal activity.
In plain English: your gut doesn't ship neurotransmitters upstairs. It sends signals up a nerve — and those signals change how your brain regulates mood, stress, and attention.
How Does Your Gut Talk to Your Brain?
Through four channels running in parallel: the vagus nerve, the enteric nervous system, microbial metabolites and neurotransmitter precursors, and the HPA axis with its inflammatory signaling. Understanding them is the difference between throwing supplements at symptoms and actually addressing the root cause.
The Vagus Nerve
The vagus nerve carries roughly 80% of its signals from the gut to the brain — not the other way around. That means your gut has more influence on your mental state than most people assume. When the vagus nerve is well-toned (high vagal tone), you recover from stress faster, sleep deeper, and regulate emotion more easily. When it's dysregulated, anxiety and brain fog become baseline states.
The Enteric Nervous System
Your gut contains its own nervous system — the enteric nervous system (ENS) — with hundreds of millions of neurons. Researchers often call it the "second brain" because it operates semi-independently of the central nervous system, regulating digestion, motility, and immune function on its own. Cleveland Clinic makes the same point about scale: outside the brain itself, there are more nerve cells in the gut than anywhere else in the body. The ENS communicates with the brain constantly through the vagus nerve and bloodstream.
Gut Microbiome and Neurotransmitters
The trillions of bacteria in your gut don't just digest food — they influence neurotransmitter systems. Bacteria synthesize compounds including serotonin, dopamine, and GABA, and shape the availability of precursors like tryptophan, which does cross into the brain. Healthline's overview of the axis[4] walks through the same chemistry, noting that enterochromaffin cells of the small intestine carry the highest concentration of serotonin in the body and that gut microbes also produce GABA. They also produce short-chain fatty acids (SCFAs) like butyrate, propionate, and acetate, which feed the cells of your gut lining, support serotonin synthesis in the gut, and influence brain function through vagal and immune signaling.
The HPA Axis and Inflammation
When you're chronically stressed, the hypothalamic-pituitary-adrenal (HPA) axis drives cortisol elevation, which damages the gut lining — loosening the tight junctions regulated by zonulin, the same barrier-gatekeeper protein covered in our gut barrier repair guide — and triggers low-grade inflammation. A human study published in Gut[5] demonstrated that acute psychological stress directly increases intestinal permeability through this exact mechanism. The result is lipopolysaccharide (LPS) leakage — inflammatory bacterial fragments enter the bloodstream, where they're increasingly studied in relation to depression, anxiety, and cognitive symptoms. A Harvard Medical School immunologist describes the vagus nerve as a direct highway[6] between gut and brain, and points to research linking microbiome disturbances to anxiety, irritability, and low mood. A comprehensive review in The Journal of Physiology[7] concluded that chronic stress disrupts every layer of the microbiota-gut-brain axis — barrier function, motility, immune signaling, and the microbiome itself.
Fix one pathway and you'll see modest improvement. Support several at once and the change is more durable.
What Are the Signs Your Gut-Brain Axis Is Out of Balance?
Seven patterns point that way, and most people don't realize their mental symptoms may be gut symptoms in disguise. If two or more of these sound familiar, your gut-brain connection likely needs support:
- Anxiety that won't quit — even when nothing's wrong. Persistent low-grade anxiety with no clear trigger often points to disrupted vagal signaling. Our breakdown of why anxiety shows up without a clear reason walks through the mechanism in detail.
- Brain fog that gets worse after meals. If you feel sharp in the morning and cognitively impaired after lunch, gut-driven inflammatory signalling is a likely contributor.
- Mood swings tied to digestion. Bloated and irritable. Constipated and low. The pattern is real — and it's the gut-brain axis talking.
- Trouble falling asleep, even when exhausted. The gut shapes tryptophan availability, and tryptophan is what your brain uses to make its own serotonin and melatonin. A disrupted gut can mean a disrupted sleep cycle.
- Cravings for sugar or processed carbs. Imbalanced gut bacteria are studied for their influence on appetite signalling — often toward sugar and refined starches.
- Bloating that comes with anxiety. When vagal tone is low, digestion slows and emotional regulation falters at the same time.
- Feeling "wired but tired." Chronic stress hammers the gut lining. A compromised intestinal barrier raises the inflammatory signalling reaching the brain, leaving you exhausted but unable to relax.
If this cluster describes you, it's worth knowing that medicine has a formal name for the recognized end of it. Disorders of gut-brain interaction (DGBI)[8] — the diagnostic category that replaced "functional gastrointestinal disorders" — covers GI symptoms that arise from changes in how the gut and brain communicate, often when standard tests come back clear. They're diagnosable and treatable, which means persistent symptoms deserve a clinician rather than a supplement protocol alone. The good news is that the underlying axis is responsive to the right ingredients, taken consistently.
Which Mental Symptoms Map to Which Gut-Brain Mechanisms?
Different mental symptoms point to different gut-brain dysfunctions. Identifying which pattern matches your experience helps you target the right intervention.
| Mental Symptom | Likely Gut-Brain Mechanism | What Targets It |
|---|---|---|
| Persistent anxiety | Low vagal tone, disrupted vagal signalling | KSM-66 ashwagandha, L-theanine, breathwork |
| Brain fog after meals | LPS leakage, gut inflammation | L-glutamine, slippery elm, marshmallow root |
| Insomnia despite fatigue | Disrupted tryptophan availability | Magnesium glycinate, gut lining support |
| Mood swings + bloating | Microbiome imbalance, vagal dysregulation | Diverse fiber, fermented foods, ashwagandha |
| Sugar/carb cravings | Microbial influence on appetite signalling | Microbiome rebalancing, blood sugar stability |
| Stress eating | HPA axis dysregulation, cortisol-driven hunger | Adaptogens, stress management, mindful eating |
| Low motivation, flat mood | Inflammatory load, dopamine precursor availability | L-tyrosine, gut support, exercise |
If your symptoms span multiple rows, you're not unusual — gut-brain dysfunction usually presents as a cluster, not a single issue. That's why single-mechanism supplements rarely work. If brain fog is the symptom you feel most, our guide to supplements for brain fog and mental clarity goes deeper on the cognitive side of the axis.
How Do Gut-Brain Axis Supplements Work?
A real gut-brain axis support supplement doesn't just dump probiotics into your system. Effective formulas work on three pathways simultaneously: vagal tone, gut lining, and systemic inflammation.
1. Supporting Vagal Tone
Adaptogens like ashwagandha lower cortisol, which is associated with better vagal tone. Better gut-brain communication means lower anxiety and faster recovery from stress.
2. Supporting the Gut Lining
Ingredients like L-glutamine, slippery elm, and marshmallow root support the intestinal barrier so fewer inflammatory compounds leak into your bloodstream. This is the foundation that everything else depends on.
3. Reducing Systemic Inflammation
Ginger root, black pepper extract, and gut-supporting herbs dial down the inflammatory signals that disrupt mood, focus, and sleep — at the source.
The most effective formulas hit all three at once. Single-ingredient supplements rarely move the needle because the gut-brain axis is a multi-pathway system.
What Are the Best Gut-Brain Axis Ingredients?
Here are the gut-brain axis ingredients with the strongest research behind them, set against the doses the studies used — including where ours sits below them.
| Ingredient | Gut-Brain Role | Studied Dose | Shuven Dose |
|---|---|---|---|
| KSM-66 Ashwagandha | Lowers cortisol, supports vagal tone | 600 mg daily over 60 days | 600 mg (Reset) — matches trial |
| L-Glutamine | Fuels the gut lining, reduces LPS leakage | 15 g daily in the permeability trial | 400 mg (Reset) — well below |
| Slippery Elm Bark | Soothes mucosal inflammation | Studied within multi-herb formulations | 200 mg (Reset) |
| Marshmallow Root | Protects intestinal barrier | Cell and tissue models; no established oral dose | 200 mg (Reset) |
| Lion's Mane | NGF support, neuroplasticity | 1.8–3 g daily across human trials | 500 mg (Focus) — below trial dose |
| Bacopa Monnieri | Memory, attention, processing speed | 300 mg daily over 8–12 weeks | 300 mg (Focus) — matches trial |
| Suntheanine L-Theanine | Calm focus, influences GABA | 200 mg daily for four weeks | 200 mg (Focus) — matches trial |
| L-Tyrosine | Dopamine precursor, motivation | Acute studies use substantially larger doses | 500 mg (Focus) |
| Ginger Root | Reduces gut inflammation | 400 mg daily in the motility review | 100 mg (Reset) — below review dose |
| BioPerine | Absorption enhancer | 5 mg, the standard studied amount | 5 mg (both) — matches |
Three rows match their trial doses exactly — ashwagandha, Bacopa, and L-theanine — and three sit below. Glutamine is the widest gap by far, because the permeability trial used gram-scale dosing no capsule can reach. We print that rather than let an ingredient list imply otherwise.
KSM-66 Ashwagandha
The most clinically studied form of ashwagandha on the market. Lowers cortisol, reduces anxiety scores, and is associated with better vagal tone — the foundation of gut-brain communication. A randomized, double-blind, placebo-controlled study in the Indian Journal of Psychological Medicine[9] found that KSM-66 at 300 mg twice daily — 600 mg total — significantly reduced serum cortisol and stress assessment scores over 60 days. Look for 300–600 mg of standardized KSM-66, not generic ashwagandha root powder. Generic ashwagandha at 100–200 mg is one of the most common underdosing patterns in commercial stress supplements.
L-Glutamine
The amino acid your gut lining uses as fuel, supporting intestinal barrier function and reducing the inflammatory signalling that drives brain fog and anxiety. A randomized, double-blind, placebo-controlled trial published in Gut[10] found that L-glutamine significantly reduced intestinal permeability alongside symptom improvement — using 5 g three times daily, 15 g in total, in adults with post-infectious IBS and confirmed permeability. That's roughly 25 capsules a day, which no capsule product delivers. Capsule-scale glutamine contributes enterocyte fuel alongside other ingredients; a powder is the honest format if you want trial-level dosing.
Lion's Mane Mushroom
A nootropic mushroom studied for its effects on nerve growth factor (NGF) — a protein that supports neuron health and cognitive function. It's one of the few natural compounds studied for a role in neuroplasticity. Human trials have used 3 g daily in adults with mild cognitive impairment and 1.8 g in a healthy-adult pilot, both above what a capsule stack typically provides. Standardization to 30% beta-glucans from fruiting body is what separates a real extract from mycelium-on-grain filler, and it matters more than the milligram number on the front of the bottle.
Suntheanine L-Theanine
The amino acid in green tea that produces calm focus without sedation. L-Theanine increases alpha brain waves (the "relaxed but alert" state) and influences GABA, dopamine, and serotonin signalling in the brain. 200 mg is the amount used in the four-week randomized trial with the strongest sleep and stress data, which is what Shuven Focus provides.
Slippery Elm Bark
A traditional demulcent that coats the gut lining and reduces irritation. A pilot clinical trial published in the Journal of Alternative and Complementary Medicine[11] found reductions in abdominal pain, bloating, and global symptom severity when slippery elm was used as part of a multi-herb formulation — which means an isolated dose can't be drawn from it. Calming the GI tract calms vagal signalling to the brain, which is particularly useful when stress triggers digestive symptoms, or vice versa.
Marshmallow Root
Works alongside slippery elm to protect the mucosal lining. Both herbs supply mucilage — a gel-like polysaccharide that physically coats and soothes the digestive tract. A study in the Journal of Ethnopharmacology[12] showed in cell and tissue models that marshmallow polysaccharides form bioadhesive layers over irritated mucosa and support epithelial cell vitality. That's laboratory evidence for the mechanism rather than a human oral trial.
Bacopa Monnieri
An Ayurvedic herb studied for memory consolidation, attention, and cognitive processing speed over 8–12 weeks of consistent use, at 300 mg of standardized extract daily. Bacopa works on the brain side of the axis while the gut-lining ingredients support the foundation. Look for standardization to 50% bacosides, the active compound group the research is built on.
Ginger Root and BioPerine Black Pepper
Ginger reduces gut inflammation and supports motility. A systematic review of clinical trials in Food Science and Nutrition[13] documented ginger's effect on gastric emptying at 200 mg twice daily, alongside carminative effects on dyspepsia and bloating. Reset contains 100 mg, working with the demulcents rather than carrying motility alone. BioPerine black pepper extract at 5 mg increases absorption of several botanicals it's paired with — which is why formulas that skip an absorption enhancer often underperform their label doses.
Which Daily Habits Strengthen the Gut-Brain Axis?
Seven practices activate the vagus nerve and support the same pathways supplements work on. Supplements work better paired with them:
- Slow nasal breathing (5 minutes daily) — directly activates the vagus nerve and shifts you out of sympathetic dominance
- Cold exposure — 30–60 seconds of cold water at the end of a shower activates vagal afferents
- Humming, singing, or gargling — physically stimulates the vagus nerve through the vocal cords
- 10-minute walk after meals — supports digestion and gut motility while reducing post-meal blood sugar spikes
- Eat one diverse fiber meal daily — feeds microbial diversity, which is closely tied to gut-brain resilience
- Limit alcohol and ultra-processed food — both damage the gut lining and reduce microbial diversity
- Prioritize sleep before 11 p.m. — your gut does much of its repair overnight
Mind-body practices belong on this list for a documented reason rather than a vague one. Harvard Health explains the mechanism behind them[14]: meditation, breathing exercises, and gut-directed hypnotherapy improve GI symptoms and mood by dampening the sympathetic nervous system, enhancing the parasympathetic response, and decreasing inflammation. You don't need to do all seven perfectly. Pick two and build from there.
What Should You Avoid in a Gut-Brain Supplement?
Most "gut-brain" supplements on the market are repackaged probiotics with marketing copy slapped on top. Watch out for:
- Proprietary blends that hide individual ingredient doses — if you can't see the milligrams, the doses are almost always too low
- Underdosed ashwagandha — anything under 300 mg of standardized extract isn't matching the clinical dose data
- No third-party testing for purity and contaminants
- Synthetic fillers like magnesium stearate, titanium dioxide, and artificial colorants
- Probiotic-only formulas that ignore the vagus nerve and gut lining entirely
- Heavy melatonin, GABA, or CBD — these mask symptoms without addressing the root mechanism, and oral GABA crosses the blood-brain barrier poorly
- Labels that hide where a dose falls short. Gram-scale ingredients like glutamine can't reach trial dose in a capsule. A formula that says so is being straight with you.
The gut-brain axis is too complex for a single-mechanism product. You need ingredients that address stress, gut lining, microbiome, and inflammation together.
How Does Shuven Support the Gut-Brain Axis?
Two formulas work together to address both ends of the connection: Reset for the gut foundation, Focus for direct cognitive support. The Shuven system was designed around the gut-brain axis from the start.
For the Gut Foundation: Shuven Reset
If you're starting from scratch or dealing with chronic gut-brain symptoms, you can start your 30-day gut-brain reset with Shuven Reset and address the underlying gut-lining and stress drivers. Each serving contains:
- KSM-66 Ashwagandha 600 mg — at its trial dose, lowering cortisol and supporting vagal tone
- L-Glutamine 400 mg — enterocyte fuel at a capsule-scale supporting amount
- Slippery Elm Bark 200 mg — soothes mucosal irritation
- Marshmallow Root 200 mg — supports the intestinal barrier
- Ginger Root 100 mg — reduces gut inflammation
- BioPerine Black Pepper 5 mg — supports absorption
No probiotics. No fillers. No proprietary blends. Every amount printed on the label, including where it sits below the research.
For Direct Cognitive Support: Shuven Focus
If your symptoms lean toward brain fog, low motivation, or scattered focus, the brain side of the axis needs direct support. You can add daytime cognitive support with Shuven Focus — a stack of Lion's Mane Extract, Bacopa Monnieri, Rhodiola Rosea, L-Tyrosine, Suntheanine L-Theanine, and BioPerine supporting neuroplasticity, neurotransmitter balance, and calm focus.
Many people start with Reset to support the foundation, then add Focus once gut-lining symptoms ease. If you want to understand what's driving the fog before choosing, our guide to what causes brain fog and how to fix it at the root covers the diagnostic side.
When Should You See a Doctor?
The gut-brain axis is real, measurable, and increasingly central to how researchers understand mental health. But supplements aren't a substitute for medical evaluation when symptoms are severe. Talk to a doctor or mental health professional if you experience:
- Persistent hopelessness or thoughts of harming yourself
- Severe anxiety that interferes with daily functioning
- Low mood lasting more than two weeks
- Significant unexplained weight loss or gain
- Inability to sleep for more than 2–3 nights in a row
- Symptoms that don't improve after 8–12 weeks of consistent supplementation and lifestyle changes
If you are having thoughts of harming yourself, please treat that as urgent rather than something to manage alone. In the United States you can call or text 988 to reach the Suicide and Crisis Lifeline, free and available 24 hours a day.
Gut-brain interventions work alongside conventional mental health care — they don't replace it. If you're already on SSRIs, thyroid medication, or blood thinners, check with your doctor before adding adaptogens like ashwagandha, which can interact with several medication classes.
Frequently Asked Questions
What is the best gut-brain axis support supplement?
The most effective gut-brain axis support supplements cover three mechanisms rather than one: an adaptogen that lowers cortisol and supports vagal tone (KSM-66 ashwagandha), gut-lining nutrients that reduce inflammatory leakage into the bloodstream (L-glutamine, slippery elm, marshmallow root), and an anti-inflammatory paired with an absorption enhancer (ginger and BioPerine). A formula that covers only the microbiome — which describes most products marketed for gut-brain support — leaves the vagus nerve and the gut barrier untouched.
Are gut-brain connection supplements the same as probiotics?
No. Probiotics add bacteria; gut-brain connection supplements target the pathways that carry signals between the gut and the brain — vagal tone, barrier integrity, inflammation, and neurotransmitter precursors. Probiotics can support the microbiome layer of that system, but they do nothing directly for a damaged gut lining or a dysregulated stress response, which are the two drivers most people actually need addressed first.
How long until I notice a difference?
Most people feel calmer and less bloated within 7–14 days. Deeper changes to mood, focus, and sleep typically appear by week 3–4, when the gut lining has had time to recover. Cognitive improvements from Lion's Mane and Bacopa often take 8–12 weeks, since they work through slower neuroplasticity pathways.
Can gut-brain supplements help with anxiety?
They can, when they target the right pathways. Adaptogens like ashwagandha lower cortisol, and gut-lining ingredients reduce the inflammatory signalling that contributes to anxiety symptoms. For a deeper protocol focused on stress and anxiety specifically, see our guide to the best supplements for stress and anxiety. Severe or persistent anxiety warrants professional assessment rather than a supplement alone.
Do I need a probiotic too?
Not necessarily. Probiotics are useful, but they don't address the root causes of gut-brain dysfunction (stress, compromised barrier, inflammation). Support the foundation first — then add a probiotic if you want. Strain matters more than colony count: Lactobacillus rhamnosus and Bifidobacterium longum have the strongest data for mood specifically.
Is this safe with my medications?
Always check with your doctor before starting any supplement, especially if you take SSRIs, blood thinners, or thyroid medication. Ashwagandha in particular can interact with thyroid and immunosuppressant drugs. Lion's Mane may potentiate the effects of blood-thinning medications.
What if I have leaky gut?
The same ingredients that support the gut-brain axis also support the gut barrier — they're addressing the same underlying mechanism. Note that "leaky gut syndrome" is not a recognized medical diagnosis, though increased intestinal permeability is real and measurable. See our complete guide to the best supplements for leaky gut repair for the full protocol and where the evidence actually stands.
Does the gut-brain axis really affect mental health?
Yes, and unlike some wellness concepts this one is recognized by mainstream medicine. Cleveland Clinic and Harvard Health both describe the connection as bidirectional and clinically meaningful, and disorders of gut-brain interaction are a formal diagnostic category[8]. The Journal of Physiology review[7] cited above concluded that gut microbiome, intestinal permeability, and vagal signaling all influence mood, anxiety, and cognitive function through measurable pathways. The honest caveat is that mechanism is better established than treatment — knowing the pathway exists doesn't mean any given supplement reliably moves it.
What's the difference between the gut-brain axis and leaky gut?
Leaky gut is a specific mechanism — increased intestinal permeability that allows inflammatory compounds to enter the bloodstream. The gut-brain axis is the broader communication system that includes permeability as one of many factors. Many people with chronic gut-brain symptoms show some degree of increased permeability, which is why gut-lining support is foundational to any gut-brain protocol.
Can stress alone cause gut-brain dysfunction?
Yes. Chronic stress is one of the most direct drivers. The human study in Gut[5] cited above showed that even acute psychological stress increases intestinal permeability within hours. Sustained stress without recovery damages the gut lining, disrupts the microbiome, and lowers vagal tone — creating the exact conditions that drive anxiety and brain fog.
The Bottom Line
The gut-brain axis isn't a wellness buzzword — it's a measurable communication system that shapes your mood, focus, sleep, and stress response. Many people who struggle with chronic anxiety, brain fog, or unexplained low mood are dealing with a gut contribution they haven't recognized.
The mechanism isn't mystical. Your gut produces most of your body's serotonin locally, signals your brain up the vagus nerve, and either supports your mental health through a diverse microbiome and intact lining — or works against it through inflammation and LPS leakage. Which of those two states you're in is heavily influenced by what you eat, how you handle stress, and whether you actively support the system.
Support the gut. The brain follows.
Start Supporting Your Gut-Brain Axis Today
You don't need to feel anxious, foggy, and exhausted as a baseline. The gut-brain axis responds to the right inputs — most people see meaningful improvement within 2–4 weeks of consistent foundational support.
If you're ready to take the next step, you can start with the 30-day Shuven Reset gut-brain foundation to address the underlying gut-lining and stress drivers, or layer in Shuven Focus for direct cognitive support if brain fog and focus are your biggest issues.
References
- Cleveland Clinic. The Gut-Brain Connection. my.clevelandclinic.org/health/body/the-gut-brain-connection
- Harvard Health Publishing. The Gut-Brain Connection. health.harvard.edu/diseases-and-conditions/the-gut-brain-connection
- Vagus nerve and serotonin signaling in the gut-brain axis, 2025 review. International Journal of Molecular Sciences. PMID: 39940928
- Healthline. The Gut-Brain Connection: How It Works and the Role of Nutrition. healthline.com/nutrition/gut-brain-connection
- Psychological stress and small intestinal permeability in healthy adults [human study]. Gut. PMID: 24153250
- Harvard Health Publishing. How the Gut-Brain Connection Influences Mood, Thought, and Well-Being. health.harvard.edu/digestive-health/how-the-gut-brain-connection-influences-mood
- Stress effects on gastrointestinal function via the microbiota-gut-brain axis [review]. The Journal of Physiology. physoc.onlinelibrary.wiley.com/doi/10.1113/JP281951
- Cleveland Clinic. Disorders of Gut-Brain Interaction (DGBI). my.clevelandclinic.org/health/diseases/disorders-of-gut-brain-interaction-dgbi
- KSM-66 Ashwagandha and serum cortisol, randomized double-blind placebo-controlled 60-day trial. Indian Journal of Psychological Medicine. PMID: 23439798
- Randomised placebo-controlled trial of dietary glutamine supplements for post-infectious IBS-D. Gut. PMID: 30108163
- Slippery elm bark as part of a multi-herb formulation, pilot trial in IBS patients. Journal of Alternative and Complementary Medicine. PMID: 20954962
- Marshmallow root polysaccharides and epithelial mucosa: cell and tissue model research. Journal of Ethnopharmacology. PMID: 19799989
- Ginger and gastrointestinal motility: systematic review of clinical trials. Food Science and Nutrition. PMCID: PMC6341159
- Harvard Health Publishing. The Brain-Gut Connection Explains Why Integrative Treatments Can Help Relieve Digestive Ailments. health.harvard.edu/blog/brain-gut-connection...
About the Author
Ryan Pepple is the founder of Shuven, where he researches and formulates supplements built around full-dose transparency — every amount on the label checked against the clinical literature it's based on.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
This article is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare practitioner before starting any new supplement, especially if you have a medical condition or take medication.
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